262 - Does severity of BPD predict neuro-developmental impairment at 5 years of age in infants born <27 weeks gestation?

Sunday, April 30, 2023

3:30 PM – 6:00 PM ET

Poster Number: 262
Publication Number: 262.34

Liza M. Espinoza, university of Calgary, Calgary, AB, Canada; Prashanth Murthy, University of Ca=ary Cumming School of Medicine, Calgary, AB, Canada; Vineet Bhandari, The Children's Regional Hospital at Cooper, Camden, NJ, United States; Selphee Tang, Alberta Health Services, Calgary, AB, Canada; Abhay K. Lodha, University of Calgary, Calgary, AB, Canada

Presenting Author(s)

ME

Maria Liza M. Espinoza, MD (she/her/hers)

Fellow
University of Calgary
Calgary, Alberta, Canada

Background:

Background: Despite improvements in perinatal care of ELBW infants and improved ventilator approaches and nutritional management, there continues to be evidence of poorer neurodevelopmental (ND) outcomes in ELBW children with BPD. However, there is no sufficient evidence to predict long-term neurodevelopmental outcomes of BPD infants at five years of age in a large study.

Objective:

To compare composite outcome of death after discharge from hospital and or ND outcomes in ELBW infants with no BPD (NBPD), mild BPD (MBPD) and severe BPD (SBPD) at 5 years of age. At our center, MBPD was defined as oxygen at 36 weeks postmenstrual age with no home oxygen and SBPD was defined as chronic oxygen dependence following discharge home.

Design/Methods:

In a prospective population-based follow-up cohort study at our regional center, all surviving babies born from Jan 1995 to Dec 2014 weighing ≤1000 g (ELBW) were enrolled in the study. Demographic, neonatal and ND outcome data were compared between the three groups. Outcomes were compared in all 3 groups using univariate and multivariable regression analysis.

Results:

Of 1033 births, 216 died, 817 survived to age 5 years and was followed in our follow-up clinic. A total 68 were excluded due to congenital anomalies. The outcome data available for 749 were grouped as follows: NBPD (N=141), MBPD (N=218) and SBPD (N=390). The lost to follow-up were also accounted, NBPD (N=36), MBPD (N=30) and SBPD (N=75) at 5 years age. Mean (SD) BWs for the three groups were 848g, 757g and 722g (p=0.001); median GAs for mild and moderate BPD were 25-26 weeks; for severe BPD 23-24 weeks (p< 0.001). Multivariate analysis showed no association between BPD severity and neuro-developmental outcome except for visual impairment. Between the 2 epochs of 1995-2005 and 2006-2014 there was no difference in neuro-developmental outcome.

Conclusion(s):

There was no association between BPD severity and death or overall ND outcomes at 5 years of age