144 - Impact of bronchopulmonary dysplasia in adolescents born extremely preterm: a multicenter cross-sectional study

Sunday, April 30, 2023

3:30 PM – 6:00 PM ET

Poster Number: 144
Publication Number: 144.362

Ryo Ogawa, Nagano Children's Hospital, azumino, Nagano, Japan; Tomohiko Nakamura, Nagano Children's Hospital, Azumino, Nagano, Japan; Fumihiko Namba, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan; Kei Tamai, National Hospital Organization Okayama Medical Center, Okayama, Okayama, Japan; Misao Kageyama, NHO Okayama Medical Center, Okayama, Okayama, Japan; Tomoko Makiya, Okinawa Chubu Hospital, Uruma, Okinawa, Japan; Chiaki Oba, Okinawa Prefectural Nanbu Medical Center Children's Medical Center, Haebaru, Okinawa, Japan; Katsuya Hirata, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan; Noriyasu Ohida, Tokyo Metropolitan Bokutoh Hospital, Sumidaku, Tokyo, Japan

Presenting Author(s)

RO

Ryo Ogawa, MD,PhD (he/him/his)

Assistant Manager
Nagano Children's Hospital
azumino, Nagano, Japan

Background: Bronchopulmonary dysplasia (BPD) continues to affect children through school age. However, the impact of BPD on adolescents is not well known.

Objective: This study aimed to evaluate the impact of BPD on adolescents who were born extremely preterm (< 28 weeks of gestation).

Design/Methods: This multicenter cross‐sectional study included adolescents who were born extremely preterm between 2003 and 2007. Questionnaires regarding the history of respiratory symptoms, asthma, allergic diseases, current disease, school performance, quality of life (QOL), and physical growth were sent to 423 participants by mail, and responses were received from 243 participants (response rate: 57.4%). The average age of the respondents was 16.5 years. The participants were divided into the following two groups: 140 and 103 in the BPD and non-BPD groups, respectively. BPD was defined as supplementary oxygen requirements for ≥28 days and the need for ≥30% oxygen and/or positive-pressure ventilation at 36 weeks postmenstrual age.

Results: One of three patients in both groups had been rehospitalized owing to respiratory symptoms; however, the difference was not significant (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.56–1.65). Respiratory syncytial virus infection was the most common reason for rehospitalization. The percentages of adolescents with ever asthma were 15.7% and 27.2% in the BPD and non-BPD groups, respectively; however, multivariate analysis showed no significant differences (adjusted OR, 0.61; 95% CI, 0.32–1.18). The percentages of adolescents with current asthma were 4.3% and 2.9% in the BPD and non-BPD groups, respectively; however, the difference was not significant (OR, 1.49; 95% CI, 0.36–6.11). Furthermore, no significant differences in the percentages of adolescents with allergic and current diseases between the two groups were observed. Adolescents requiring special classes/school tended to be more frequent in the BPD group (OR, 2.14; 95% CI, 0.98–4.66). QOL scores were similar in both groups (71.0 vs. 71.9, p = 0.61). The z-scores for body weight were −0.79 and −0.50 in the BPD and non-BPD groups, respectively; the z-scores for height were −0.95 and −0.58 in the BPD and non-BPD groups, respectively. Both were significantly different (p = 0.01).

Conclusion(s): Adolescents born extremely prematurely with BPD were smaller physically than those without BPD. No significant differences in rehospitalization, asthma, and QOL scores between the two groups were noted. To determine the impact of BPD on adults, further studies are needed.