68 - Association of prenatal MgSO4 exposure and gastrointestinal mobidities among very preterm infants: a multicenter cohort study

Saturday, April 29, 2023

3:30 PM – 6:00 PM ET

Poster Number: 68
Publication Number: 68.235

yujie han, Children's Hospital Affiliated to Shandong University, jinan, Shandong, China (People's Republic); Siyuan Jiang, Children's Hospital of Fudan University, Shanghai, Shanghai, China (People's Republic); Xinyue Gu, Children's Hospital of Fudan Umiversity, Shanghai, Shanghai, China (People's Republic); Wenhao Zhou, Children's Hospital of Fudan University, Shanghai, Shanghai, China (People's Republic); Yun Cao, Children's Hospital of Fudan University, Shanghai, PCR, Shanghai, Shanghai, China (People's Republic); Shoo K. Lee, University of Toronto Temerty Faculty of Medicine, Toronto, ON, Canada; xiaoying Li, Children's Hospital Affiliated to Shandong University, JInan, Shandong, China (People's Republic); Yanping Zhu, Xinjiang Medical University, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (People's Republic)

Presenting Author(s)

yh

yujie han (she/her/hers)

No.23976 Huaiyin District, Jinan City, Shandong Province,China
Children's Hospital Affiliated to Shandong University
jinan, Shandong, China (People's Republic)

Background:

With the widespread use of prenatal magnesium sulfate(MgSO4), there are still concerns whether MgSO4 will increase risk of necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) among very preterm infants (VPIs).

Objective:

To evaluate the association between prenatal MgSO4 exposure and NEC, SIP and/or death using the largest contemporary cohort of VPIs in China from the Chinese Neonatal Network (CHNN).

Design/Methods:

This retrospective cohort study enrolled all infants born at 24-31 weeks’ gestation and admitted to NICUs participating in CHNN from January, 2019 to December, 2021. Infants with major congenital anomalies and missing MgSO4 information were excluded. The primary outcome was a composite of NEC, SIP and/or death. Multivariable logistic regression analysis was used to assess the association of MgSO4 and neonatal outcomes. Subgroup analyses were done among infants with different gestational age, antenatal steroid use, and maternal hypertension.

Results:

A total of 24058 infants were included, with 12799(53.2%) infants exposed to prenatal MgSO4. Infants with pernatal MgSO4 exposure were more likely to be born to mothers with hypertension, to receive antenatal steroids, to have lower birth weight, and to be small for gestaional age (Table 1). The incidence of NEC, SIP and/or death was lower in MgSO4 group compared with non-MgSO4 group (15.0% vs 16.7%, P=0.0003) (Table 2). After adjustment, there was no significant association between prenatal MgSO4 and the risk of NEC, SIP and/or death (aOR:1.081,95%CI:0.98-1.193). There was also no association between MgSO4 and NEC, SIP and/or death occurring within 14 days after birth (aOR:1.036,95%CI:0.91-1.19). Subgroups analysis by different gestational ages (24-26 weeks, 26-28 weeks,29-31 weeks), maternal antenatal corticosteroids, and maternal hypertension showed similar results.

Conclusion(s):

Prenatal MgSO4 exposure was not associated with increased risk of NEC, SIP or death among very preterm infants.