NICU Follow Up and Neurodevelopmental 2: Neonatal Growth, Nutrition and the Brain
212 - Height trajectories in extremely preterm non-small-for-gestational age Japanese infants
Friday, April 28, 2023
5:15 PM – 7:15 PM ET
Poster Number: 212 Publication Number: 212.144
Megumi Seya, Tokyo metropolitan Ohtsuka hospital, Bunkyo-ku, Tokyo, Japan; Nobuhiko Nagano, Department Pediatrics and Child Health, Nihon Uviversity School of Medicine, Itabashi-ku, Tokyo, Japan; Aya Okahashi, Nihon university school of medcine, Itabashi, Tokyo, Japan; Shoko Ohashi, tokyo metropolitan ohtsuka hospital, toshimaku,minamiohtsuka, Tokyo, Japan; Ken Masunaga, Tokyo metropolitan Ohtsuka hospital, tokyo, Tokyo, Japan; Ichiro Morioka, Nihon University School of Medicine, Itabashi, Tokyo, Japan
Associate professor Department Pediatrics and Child Health, Nihon Uviversity School of Medicine Itabashi-ku, Tokyo, Japan
Background: Small-for-gestational age (SGA), who were born extremely preterm, have a very high risk of being short in stature. However, the risk in extremely preterm non-SGA infants is not known. Objective: To characterize the trajectory and catch-up rate of height in extremely preterm non-SGA infants up to 6 years of age. Design/Methods: 214 Japanese extremely preterm infants (< 28 wks’ GA) who were born at Tokyo metropolitan Ohtsuka hospital between 2007 and 2011, 160 infants were included after the approval of the Ethics Committee and parental consent. 54 infants (23: died; 2: chromosomal abnormalities; 5: non-Japanese; 24: transferred to other hospitals before their follow-up) were excluded. Infants were classified into those SGA and non-SGA. SGA was defined as a birthweight < 10th percentile. Height Z-scores and height catch-up rates at 3-4 and 9-10 months-corrected age, and 2, 3, and 6 years of age were calculated. Catch-up was defined as infants whose height reached ≥-2 SD and the rates were calculated. All data were compared between the groups. Results: In the 160 extremely preterm infants, 129 (81%) were non-SGA and 31 (19%) were SGA. 2 SGA infants received growth hormone therapy for severe short stature at 3 years of age. Height Z-scores were significantly lower in SGA than non-SGA group at all ages (p< 0.001, Table 1). However, non-SGA infants had negative Z-scores even at 6 years of age. The height catch-up rates were significantly lower in SGA than non-SGA infants at 9–10 months of age, but remained at 90% in non-SGA infants at 6 years of age (p< 0.05, Table 1).
Conclusion(s): More than 50% and 20% of extremely preterm SGA infants developed short stature at 3 and 6 years of age, respectively, as previously reported. Even non-SGA infants also appear short stature (negative Z-scores in median) up to 6 years of age and around 15% and 10% developed short stature at 3 and 6 years of age, respectively. We suggest that because those extremely preterm non-SGA infants who do not catch-up in height may need growth hormone therapy.
