717 - Intracranial hemorrhages in infants of diabetic mothers: A national cohort study

Saturday, April 29, 2023

3:30 PM – 6:00 PM ET

Poster Number: 717
Publication Number: 717.234

Mohsen A.A.. Farghaly, Cleveland Clinic Children's, Cleveland, OH, United States; Ibrahim Qattea, Nassau University Medical center, East Meady, NY, United States; Mahmoud A.M.. Ali, Case Western Reserve University School of Medicine, North olmsted, OH, United States; Firas Saker, Cleveland Clinic Children's, Cleveland, OH, United States; Mohamed A. Mohamed, Cleveland Clinic Children's, Cleveland, OH, United States; Hany Aly, Cleveland Clinic Children's, Cleveland, OH, United States

Presenting Author(s)

Mohsen A.A Farghaly, MD

Doctor
Cleveland Clinic Children's
Cleveland, Ohio, United States

Background:

There are multiple mechanisms that could plausibly increase the risk of brain hemorrhages in infants of diabetic mothers (IDMs). However, the association of maternal DM and neonatal intracranial hemorrhages has not been previously studied.

Objective: To assess the association of maternal diabetes mellitus (DM) with intraventricular hemorrhage (IVH) and other intracranial hemorrhages (ICH) in newborns.

Design/Methods: We analyzed the National Inpatient Sample dataset and compared prevalence of IVH and other subtypes of ICH in infants of diabetic mothers (IDMs) vs. those born to mothers without DM. Regression models were used to control for demographic and clinical confounding variables.

Results: A total of 11,318,691 infants were included. Compared to controls, IDMs had increased prevalence of IVH (aOR=1.18, CI: 1.12-1.23) and ICH (aOR=1.18, CI: 1.07-1.31). Severe IVH (grades 3 & 4) was encountered less frequently in IDMs (aOR=0.75, CI: 0.66-0.85) than controls. Gestational DM was only associated with subarachnoid hemorrhage (aOR=1.60, CI: 1.11-2.31), and was not associated with IVH or other ICH.

Conclusion(s):

Maternal DM is associated with increased neonatal ICH and IVH but not severe IVH.