200 - Relationship Between Mean Platelet Volume and glycemic Control in Pediatric Population with Diabetes

Poster Number: 200
Publication Number: 200.214

Uday Tiwari, Brookdale University Hospital Medical Center, Brooklyn, NY, United States; Haiyan Lu, one Brooklyn Medical Center, New York, NY, United States; Min Kyung Jung, New York Institute of Technology College of Osteopathic Medicine, Oakland Gardens, NY, United States; Kusum Viswanathan, OBH Brookdale Hospital Medical Center, Brooklyn, NY, United States; Fernanda E. Kupferman,, One Brooklyn Health @ Brookdale Hospital Medical Center, Brooklyn, NY, United States

Background: Diabetes is a major public health problem in the USA and the incidence is increasing. According to CDC (Centers for Disease Control) estimates in 2018 around 25 per 10,000 people less than age 20 years had diabetes. Micro vascular and macro vascular diseases are well known complications in patients with diabetes. Increased platelet activity is responsible for the development of vascular complications. Platelets which are more active and younger are larger, i.e., high MPV (Mean Platelet Volume). Numerous studies have shown poor glycemic control in diabetic patients is associated with high MPV but to the best of our knowledge such studies targeting only pediatric population are lacking.

Objective: To assess the association of HbA1C with MPV in pediatric population with diabetes

Design/Methods: We retrospectively collected clinical data of diabetic patients aged 0-21 years following by the pediatric endocrinology clinic at our institution from 2015 to 2021 with the hospital’s electronic medical records (EPIC system). MPV was taken from CBC done within last 3 months prior to HbA1C. Pearson correlation coefficient was computed to study a linear association of the MPV with HbA1C level and the student’s t-test was performed to compare the mean MPV (Mean Platelet Volume) between the two groups of glycemic controlled (HbA1C =< 7.5) and uncontrolled (HbA1c >7.5).

Results: We collected data from 312 subjects for our study out of which 39 were excluded based on exclusion criteria. So, 273 subjects were included in our study. Descriptive statistics of demographic variables are shown in table 1. MPV was significantly higher in the glycemic uncontrolled group as compared to the controlled group [9.5 (1.0) vs 7.9 (0.9), P < 0.001]. This significant difference between HbA1C and MPV remains true even when subjects were divided into subgroups based on race and BMI as shown in table 2. MPV was strongly correlated with HbA1C (correlation coefficient of 0.58, p < 0.001) as shown in figure 1. 

Conclusion(s): MPV was higher in uncontrolled glycemic group than in controlled group of pediatric diabetic population. Further studies are necessary to identify the long-term consequence of higher MPV in uncontrolled groups.