56 - Characteristics and Risk Factors of SARS-CoV-2 Associated Transaminemia in Pediatric Patients

An IRB-approved retrospective chart review of pediatric patients evaluated at two neighboring medical centers between March 2020 to March 2022 in Brooklyn, NY. Our review included all p</span>atients up to and including 18 years of age with a positive SARS-CoV-2 PCR test and CMP performed at the same visit. Patients who were diagnosed with MISC during the hospitalization were excluded.  

Patient demographics were assessed as well as hepatitis status, presence of GI symptoms and estimated variant type based on population sequencing data. Data analysis was performed using SPSS with a significance of 0.05. Data were analyzed using student’s T-test and Chi square between the groups.  


Results: Ninety-four patient records were included, with a summary in Table 1. No patients had progressive liver injury, with all demonstrating recovery. Race, ethnicity, gender, history of pre-existing medical conditions and BMI were not significantly associated with SARS-CoV-2 hepatitis. The mean age of hepatitis patients was significantly younger (Hepatitis vs non-hepatitis: 7.1 ± 6.4 vs. 12.1 ± 5.9 years; p < 0.001). Hepatitis patients were more likely to be admitted for care (p = 0.021) and report the presence of gastrointestinal symptoms at the time of admission (Hepatitis vs non-hepatitis: 51% vs 29%, p</span> = 0.029).

 

Conclusion(s):

Our study demonstrates a reassuring clinical history of SARS-CoV-2 associated transaminemia, but does note interesting patterns. First, risk of transaminemia appears higher in younger patients. Second, risk of transaminemia appears to be strongly linked with the presence of gastrointestinal symptoms, which may reflect an increase in hepatic viral exposure.