Basic-Translational-Clinical Roundtable

Basic Science

Child Abuse & Neglect

Children with Chronic Conditions

Clinical Research

Developmental Biology

General Pediatrics

Health Equity/Social Determinants of Health

Wellness and Well-being

Session Type: Basic-Translational-Clinical Roundtable

From Cells to Society: Clinical translational approaches to treating toxic stress in the pediatric primary care setting.

Sunday, April 30, 2023

2:00 PM – 3:30 PM ET

Location: Convention Center: 103 A

CE: Live CME: 1.50

Selected By: SDBP

Chair(s)

Mikah Owen, MD, MPH, MBA (he/him/his)

Senior Clinical and Academic Program Director, Health Equity
UCLA-UCSF ACEs Aware Family Resilience Network , United States

Disclosure(s):

Mikah Owen, MD, MPH, MBA: No financial relationships to disclose

Session

Description: Stress is on everyone’s mind but in no one’s medical record. The landmark Adverse Childhood Experiences study sparked a wave of research demonstrating a link between childhood adversity and long-term mental and physical health outcomes including but not limited to asthma, ADHD, learning and behavior issues, addiction, anxiety, and depression. Research highlights toxic stress, the prolonged activation of the stress response system and subsequent disruptions of neuroendocrine, immune, and genetic function, as an underlying mechanism by which childhood adversity gets “under the skin.” While many agree that childhood adversity is a public health crisis, there is less clarity on how to translate population level research data into clinical practice. In this roundtable a panel of translational researchers and clinicians will explore how understanding the science of the stress physiology can provide an opportunity for developing novel diagnostic tools and treatment strategies for healing toxic stress and preventing long-term health issues.

George Slavich PhD will highlight his cellular research examining stress physiology and biomarkers. Rachel Gilgoff MD will discuss the clinical translation, providing the science on safe and promising clinical interventions for toxic stress. Robin Ortiz MD MPH will discuss structural and environmental implications of toxic stress and provide a health equity and community level framework. Devika Bhushan MD MPH will describe lessons learned from California policy and the ACEs Aware Initiative advancing universal ACE screening in primary care. Together, this panel will offer a path for incorporating stress biology on multiple levels: cellular, individual, dyad, family, community, policy and society.

Learning Objectives:

Describe how the science of stress biology can be applied to our clinical response for children who have experienced early life adversity.
Apply existing theoretical frameworks such as dyadic behavior change and community based participatory research to address toxic stress at the dyadic, family and community levels.
Define and give examples of cross-sector approaches and policy-level interventions to achieve primary, secondary, and tertiary prevention of childhood adversity and toxic stress.

Presentations:

2:00 PM – 2:10 PM ET

Introduction
Chair: Mikah Owen, MD, MPH, MBA (he/him/his) – UCLA-UCSF ACEs Aware Family Resilience Network
2:10 PM – 2:25 PM ET

Stress, Psychobiological Mechanisms, and Translational Biomarkers
Speaker: George Slavich, PhD (he/him/his) – UCLA
2:25 PM – 2:40 PM ET

Toxic Stress Physiology and Individual Healing
Speaker: Rachel Gilgoff, MD (she/her/hers) – UCLA
2:40 PM – 2:55 PM ET

Expanding Stress Biology to the Dyad, Family, and Community
Speaker: Robin Ortiz, MD, MSHP (she/her/hers) – NYU Grossman School of Medicine/Institute for Excellence in Health Equity
2:55 PM – 3:10 PM ET

Healing from Toxic Stress: A Policy Approach
Speaker: Devika Bhushan, MD, FAAP – ACEs Aware Initiative
3:10 PM – 3:30 PM ET

Q&A