Hot Topic Debates: Antimicrobial Use in Neonates

Monday, May 1, 2023

1:00 PM – 2:30 PM ET

Location: Convention Center: 146 A

CE: Live CME: 1.50

Selected By: PIDS Independent
Co-sponsored By: AAP SoNPM

Chair(s)

Matthew Kronman, MD, MSCE (he/him/his)

Professor, Pediatric Infectious Diseases
Pediatrics, Division of Infectious Diseases
University of Washington School of Medicine
Seattle, Washington, United States
Preeti Jaggi, MD (she/her/hers)

Associate Professor of Pediatrics, Division of Infectious Diseases
Children's Healthcare of Atlanta
atlanta, Georgia, United States

Disclosure(s):

Matthew Kronman, MD, MSCE: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Preeti Jaggi, MD: No financial relationships to disclose

Session

Description: This session will involve 3 debates on clinically relevant hot topics relating to antimicrobial use for neonates, including whether and when enteral antibiotics are appropriate for the management of hospitalized neonates; whether antibiotic therapy should be provided for neonates with “culture negative sepsis” and for how long; and whether febrile neonates undergoing sepsis evaluation should receive empiric acyclovir. During this session, national leaders in Infectious Diseases will debate these topics. The format will involve three 30 minute debates, in which each speaker will review the scientific evidence for their position for 8-10 minutes (20 minutes total), respond to the other speaker for 2 minutes (4 minutes total), and then garner audience participation through live polling and questions for the remaining 6-10 minutes total. The presentation of the initial position could be pre-recorded if needed, while the rebuttals and Q&A section would ideally be live. The overarching goal of the session is to highlight the evidence for and against the antibiotic management strategies covered for these common situations in hospitalized neonates, and to provide a fun and interactive session reaching a broad multidisciplinary audience.

This engaging session will therefore be relevant to those who care for hospitalized neonates, including medical student and resident trainees, general pediatricians, hospitalists, and specialists in emergency medicine, neonatology, and infectious diseases.

Learning Objectives:

Describe the data for and against use of enteral antimicrobials in neonates.
Review situations in which antibiotics should be provided to neonates with culture-negative sepsis, and the risks and benefits associated with that therapy.
Evaluate the data for, and risks and benefits of, empiric acyclovir use for febrile neonates undergoing sepsis evaluation.

Presentations:

1:00 PM – 1:02 PM ET

Hot Topic Debates: Antimicrobial Use in Neonates - Introduction
Speaker: Matthew Kronman, MD, MSCE (he/him/his) – University of Washington School of Medicine
1:02 PM – 1:04 PM ET

Hot Topic Debates: Antimicrobial Use in Neonates - Introduction
Speaker: Preeti Jaggi, MD (she/her/hers) – Children's Healthcare of Atlanta
1:04 PM – 1:18 PM ET

Antibiotic therapy for infections in neonates should only be administered IV - PRO
Speaker: Gail J. Demmler Harrison, MD (she/her/hers) – Baylor College of Medicine
1:18 PM – 1:32 PM ET

Antibiotic therapy for infections in neonates should only be administered IV - CON
Speaker: Andrew S. Haynes, MD MA – Children's Hospital Colorado
1:32 PM – 1:46 PM ET

Culture negative sepsis in the NICU should be treated for 5 days - PRO
Speaker: Pavel Prusakov, PharmD (he/him/his) – Nationwide Children's Hospital
1:46 PM – 2:00 PM ET

Culture negative sepsis in the NICU should be treated for 5 days - CON
Speaker: Joseph B. Cantey, MD, MPH (he/him/his) – The University of Texas Health Science Center at San Antonio Joe R. and Teresa Lozano Long School of Medicine
2:00 PM – 2:15 PM ET

Acyclovir should be used for the empiric management of febrile neonates < 4 weeks undergoing full sepsis evaluation - PRO
Speaker: Asuncion Mejias, MD, PhD, MsCS (she/her/hers) – St Jude Children's Research Hospital
2:15 PM – 2:30 PM ET

Acyclovir should be used for the empiric management of febrile neonates < 4 weeks undergoing full sepsis evaluation - CON
Speaker: Keerti Dantuluri, MD, MPH – Levine Children's Hospital at Atrium Health