Milk & Microbes: Optimizing Early Nutrition & Response to Microbial Exposures to Reduce Inequities in Cardiometabolic Disease

Monday, May 1, 2023

8:00 AM – 9:30 AM ET

Location: Convention Center: 150 A

CE: Live CME: 1.50

Selected By: MOD
Co-sponsored By: MOD, PIDS, AAP SoNPM, Endo

Chair(s)

Andi Shane, MD, MPH, MSc

Professor of Pediatrics Division Chief, Pediatric Infectious Disease
Emory University and Children's Healthcare of Atlanta
Atlanta, Georgia, United States
NM

Nathalie Maitre, MD, PhD (she/her/hers)

Professor of Pediatrics
Emory + Children’s Pediatric Institute
atlanta, Georgia, United States

Disclosure(s):

Andi L. Shane, MD, MPH, MSc: International Scientific Association for Probiotics and Prebiotics (ISAPP): Speaker Honorarium including speakers bureau, symposia, and expert witness (Terminated, June 17, 2022)

Nathalie Maitre, MD, PhD: Enlighten Mobility (Ongoing) (Products/Services: Intellectual Property including patent beneficiary and royalties); Thrive Neuromedical (Ongoing) (Products/Services: Ownership Interest including individual stocks, stock options, excluding diversified mutual funds)

Session

Description: Early life exposure to colonizing and pathogenic microbes shapes immune and inflammatory responses impacting the risk of cardiovascular and metabolic (cardiometabolic) disease across the life course. Responses and interventions to presumptive and confirmed infections, including antimicrobial therapies and vaccination, impact inflammatory responses during key phases of childhood development and maturation. These microbial exposures and their short- and long-term effects on cardiometabolic risk are profoundly affected by infant feeding, particularly human milk. Three internationally recognized experts in infection and inflammation, cardiometabolic risk, neonatal nutrition, and endocrinology/obesity will discuss a life course approach to understanding and preventing adverse cardiometabolic disease, emphasizing human milk as a key intervention. Their multidisciplinary perspectives will be applied to develop a framework for positively impacting long term cardiometabolic health. Presenter-panelists will address health inequities associated with exposures and early measures, including access to care and resources that optimize health outcomes. Moderated by a neonatologist and an infectious disease clinical researcher, the presenter-panelists will engage in a discussion that will lead to awareness and strategies that could be adopted into a life course strategy for improved cardiometabolic health.
1.

Introduction: Andi Shane
2. Early life infection and inflammation – under-appreciated targets for risk-stratification and prevention: David Burgner
3. Mighty Milk: The impact of breastfeeding on microbiome composition, infection, inflammation and cardiometabolic risk: Meghan Azad
4. Thinking outside the (lunch) box: earlier and more effective prevention of the adverse effects of obesity from birth: Danielle Longmore
5. Panel discussion: Andi Shane and Nathalie Maitre (moderators)
6. Conclusions and Summary

Learning Objectives:

Apply a life course framework to understanding the evidence that early life nutrition, infection and inflammation, and access to resources, impact lifelong cardiometabolic risk
Discuss the role of management of infections and inflammation in supporting healthy microbiome acquisition and retention throughout the life course
Define and address the modifiable factors related to neonatal and childhood nutrition that impact cardiometabolic health

Presentations:

8:00 AM – 8:15 AM ET

Overview and background and introduction of speakers and objectives/ Moderate panel discussion
Speaker: Andi L. Shane, MD, MPH, MSc – Emory University and Children's Healthcare of Atlanta
8:15 AM – 8:35 AM ET

Early life infection and inflammation – under-appreciated targets for risk-stratification and prevention
Speaker: David Burgner, MD PhD (he/him/his) – Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia
8:35 AM – 8:55 AM ET

Mighty Milk: The impact of breastfeeding on microbiome composition, infection, inflammation and cardiometabolic risk
Speaker: Meghan Azad, PhD – University of Manitoba
8:55 AM – 9:15 AM ET

Thinking outside the (lunch) box: Earlier and more effective prevention of the adverse effects of obesity from birth
Speaker: Danielle K. Longmore, B.Med (Hons), MPHTM, FRACP, PhD (she/her/hers) – Murdoch Children's Research Institute
9:15 AM – 9:30 AM ET

Moderate panel discussion / Conclusions and summary
Speaker: Nathalie Maitre, MD, PhD (she/her/hers) – Emory + Children’s Pediatric Institute