PAS Postgraduate Course: Genomics in Newborn Care

Friday, April 28, 2023

7:00 AM – 1:30 PM ET

Chair(s)

Pankaj Agrawal, MD MMSC

Professor of Pediatrics and Genetics (pending)
Newborn Medicine and Genetics & Genomics
University of Miami
Miami, Florida, United States
LN

Lawrence Nogee

Professor of Pediatrics
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States

Disclosure(s):

Pankaj b. Agrawal, MD MMSC: GeneDx: Advisory Committee (Ongoing); Illumina, Inc.: Advisory Committee (Terminated, December 9, 2020)

Lawrence M. Nogee, MD: United Therapeutics: Research Support including clinical trials & the principal or named investigator (Terminated, January 14, 2022); Wolters Kluwer: Intellectual Property including patent beneficiary and royalties (Ongoing)

Session

Description: A post graduate course focusing on the implementation of genomic care in newborns and the available clinical, translational and research opportunities.The course will cover the entire spectrum of applications of genomic medicine in newborns. In addition to an overview, we will cover various aspects of genomics including need for rapid sequencing, cost-effectiveness, genetic basis of various neonatal conditions, implementation experience in the NICU, and ethical, legal, social implications and issues of diversity and equity. The topics will include: 1. An overview of the genomic care in newborns by Dr. Pankaj Agrawal; 2. Rapid genome sequencing and cost effectiveness by Dr. Nathaly Sweeney; 3.Southseq, a NIH-funded study of sequencing newborns by Dr. Bruce Korf; 4. Implementing genomic care in a Level 4 NICU by Dr. Tara Wenger; 5. Blessings and pitfalls of genetic testing in Newborns by Dr. Rita Ryan; 6. Role of genomic sequencing in newborn screening by Dr. Ingrid Holm; 7. Genetic basis of cardiac defects by Dr. Sarah Morton; 8. Genetic basis of neonatal lung conditions and Gene therapy approach to genetic surfactant deficiency by Dr. Jennifer Wambach; 9. Genetic basis of prematurity by Dr. Lou Muglia; 10. Ethical, social and legal implications in implementing newborn genomic care by Dr. Monica Wojcik and 11. Resolving racial, equity and diversity issues in genomics by Dr. Tamora Lewis.

Learning Objectives:

Upon completion, participants will be able to understand how genomic applications can improve the care of newborns especially in theNICUs.
Upon completion, participants will be able to determine the role of rapid sequencing in the NICU, genetic basis of various neonatal conditions, and research opportunities.
Upon completion, participants will be able to learn implementation experience, its cost-effectiveness, ethical, legal, social implications, and issues of diversity and equity in genomic applications.

Presentations:

7:00 AM – 7:30 AM ET

An overview of the genomic care in newborns
Speaker: Pankaj B. Agrawal, MD MMSC – University of Miami
7:30 AM – 8:00 AM ET

Southseq: a NIH-funded study of sequencing newborns
Speaker: Bruce R. Korf, MD, PhD – UAB Heersink School of Medicine
8:00 AM – 8:30 AM ET

Implementing genomic care in a Level 4 NICU
Speaker: Tara L. Wenger, MD, PhD (she/her/hers) – University of Washington
8:30 AM – 9:00 AM ET

Blessings and pitfalls of genetic testing in Newborns
Speaker: RIta M. Ryan, MD – UH Rainbow Babies & Children's Hospital
9:00 AM – 9:30 AM ET

Role of genomic sequencing in newborn screening
Speaker: Ingrid A. Holm, MD, MPH (she/her/hers) – Harvard Medical School / Boston Children's Hospital
9:30 AM – 10:00 AM ET

Genetic basis of congenital cardiac defects
Speaker: Sarah U. Morton, MD PhD – Boston Children's Hospital/Harvard Medical School
10:00 AM – 10:30 AM ET

Genetic basis of neonatal lung conditions and gene therapy approach to congenital surfactant deficiency
Speaker: Jennifer Wambach, MD, MS (she/her/hers) – Washington University in St. Louis School of Medicine
10:30 AM – 11:00 AM ET

Genetic basis of prematurity
Speaker: Louis Muglia, MD, PhD (he/him/his) – Burroughs Wellcome Fund
11:00 AM – 11:30 AM ET

Ethical, social and legal implications in implementing newborn genomic care
Speaker: Monica Wojcik, MD, MPH, FAAP, FACMG – Boston Children's Hospital
11:30 AM – 12:00 PM ET

Resolving racial, equity and diversity issues in genomics
Speaker: Tamorah Lewis, MD, PhD (she/her/hers) – University of Toronto Temerty Faculty of Medicine
12:00 PM – 12:30 PM ET

Rapid genome sequencing and cost effectiveness
Speaker: Nathaly Sweeney, MD, MPH, MS – University of California, San Diego School of Medicine