Cerebral injuries in intraventricular hemorrhage and emerging therapies

Friday, April 28, 2023

3:45 PM – 5:15 PM ET

Location: Convention Center: 147 AB

CE: Live CME: 1.50

Selected By: NBS
Co-sponsored By: CNS, AAP SoNPM

Chair(s)

Praveen Ballabh, MD

professor
ALBERT EINSTEIN COLLEGE OF MEDICINE
Bronx, New York, United States
Linda de Vries, MD PhD (she/her/hers)

Em Prof Neonatal neurology
Neonatology
University medical center Utrecht
Utrecht, Netherlands

Disclosure(s):

PRAVEEN BALLABH, MD: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Linda S. de Vries, MD PhD: No financial relationships to disclose

Session

Description: Intraventricular hemorrhage (IVH) damages both the adjacent white matter and the distant cerebral gray matter. IVH destroys the germinal matrix, suppresses neurogenesis, oligodendrogenesis, and disrupts both white and gray matter development. The pathogenesis of injury is attributed to IVH-induced oxidative stress, inflammation, and mass effect damaging the germinal matrix as well as to posthemorrhagic ventricular dilation (PHVD). Neuroimaging has enhanced our perception of both cerebral gray and white matter injuries and is a valuable predictor of neurodevelopmental outcomes. Potential therapies for IVH are under investigation in preclinical models, and evidence from clinical trials suggests that removal of the blood clot, and strategies to promote myelination, neurogenesis, reducing inflammation and oxidative stress would enhance the outcome of the survivors of IVH.

Learning Objectives:

Discuss recent advances in the understanding of the pathogenesis of white matter and gray matter injuries in premature infants.
Review neuroimaging studies on structural and functional connectivity in infants with IVH.
Critically discuss the advances and controversies in the management of Posthemorrhagic Hydrocephalus and emerging therapies for survivors of IVH.

Presentations:

3:45 PM – 4:05 PM ET

Pathogenesis of white and gray matter injuries in intraventricular hemorrhage.
Speaker: Praveen Ballabh, MD – ALBERT EINSTEIN COLLEGE OF MEDICINE
4:05 PM – 4:20 PM ET

Neuroimaging of structural and functional connectivity in preterm Infants with intraventricular hemorrhage
Speaker: Christopher D. Smyser, MD, MSDCI (he/him/his) – Washington University in St. Louis
4:20 PM – 4:35 PM ET

Advances in the management of Posthemorrhagic Hydrocephalus
Speaker: David Limbrick, MD, PhD – Washington University in St. Louis School of Medicine
4:35 PM – 4:50 PM ET

Evidence-based management of survivors with intraventricular hemorrhage.
Speaker: Andrew Whitelaw, MD, FRCPCH (he/him/his) – University of Bristol
4:50 PM – 5:05 PM ET

Preclinical and clinical experience of Stem cell therapy in intraventricular hemorrhage
Speaker: Won Soon Park, MD, PhD – Gangnam Cha Hospital
5:05 PM – 5:15 PM ET

Questions and answer session will be chaired by Dr. Linda de Vries
Speaker: Linda S. de Vries, MD PhD (she/her/hers) – University medical center Utrecht