PAS SIG: Clinical Pharmacology & Therapeutics

Friday, April 28, 2023

3:45 PM – 5:15 PM ET

Location: Convention Center: 140 A

CE: Live CME: 1.50

SIG Speaker(s)

Kevin Watt, MD, PhD

Associate Professor
University of Utah School of Medicine
Salt Lake City, Utah, United States

SIG Chair(s)

Kevin Watt, MD, PhD

Associate Professor
University of Utah School of Medicine
Salt Lake City, Utah, United States

SIG Speaker(s)

Mark Hall, MD

Chief, Division of Critical Care Medicine
Nationwide Children's Hospital
Columbus, Ohio, United States
Kathleen Job, PhD, DABCP

Research Assistant Professor
University of Utah, United States
Brian Smith, MD MPH MHS (he/him/his)

Samuel L. Katz Professor of Pediatrics
Duke
Durham, North Carolina, United States

Disclosure(s):

Kevin Watt, MD, PhD: No financial relationships to disclose

Mark W. Hall, MD: Abbvie: Consultant (Ongoing); American Board of Pediatrics: Consultant (Ongoing); Kiadis: Intellectual Property including patent beneficiary and royalties (Ongoing); Partner Therapeutics: Research Support including clinical trials & the principal or named investigator (Ongoing); Sobi: Research Support including clinical trials & the principal or named investigator (Ongoing)

Kathleen Job, PhD, DABCP: No financial relationships to disclose

Brian Martin Smith, MD MPH MHS: Provepharm (Ongoing) (Products/Services: Consultant); Syneos (Ongoing) (Products/Services: Consultant); Tellus (Ongoing) (Products/Services: Consultant); UCB (Ongoing) (Products/Services: Consultant)

Session

Description: The majority of drugs used to treat children are not labeled for use in children. Off-label prescribing places children at risk for therapeutic failure and toxicity. Pediatric clinical pharmacology seeks to address these issues by identifying knowledge gaps, conducting research, and disseminating knowledge. The discipline is collaborative and relevant to all disease areas in pediatrics. There is a global shortage in qualified trained pediatric clinical pharmacologists with approximately one pediatric clinical pharmacologist for every four million children. This session will highlight ways in which clinical pharmacology is directly impacting child health from fetus through adolescence and across disease states with a particular focus to encourage interest from junior investigators. The session will conclude with an interactive panel discussion, designed to facilitate discussion of high-impact clinical questions, strategies for multi-institutional collaboration for research, and opportunities for junior investigators.

Learning Objectives:

a. Understand how clinical pharmacology can determine optimal dosing across the age spectrum
b. Understand how clinical pharmacology is incorporated into clinical trials
c. Discussion of research priorities, collaborative opportunities, and strategies for clinical implementation

Presentations:

3:45 PM – 4:05 PM ET

Junior faculty/trainee activity
Speaker: Kevin Watt, MD, PhD – University of Utah School of Medicine
4:05 PM – 4:25 PM ET

Clinical Pharmacology in Practice – The PRECISE Trial
Speaker: Mark W. Hall, MD – Nationwide Children's Hospital
4:25 PM – 4:45 PM ET

Drug exposure in the fetus and newborn – understanding the extent of maternal transfer of drugs
Speaker: Kathleen Job, PhD, DABCP – University of Utah
4:45 PM – 5:05 PM ET

Pediatric Dosing – 10 years of the Pediatric Trials Network
Speaker: Brian Smith, MD MPH MHS (he/him/his) – Duke