38th Annual Audrey K. Brown Kernicterus Symposium

Monday, May 1, 2023

11:30 AM – 1:00 PM ET

Location: Convention Center: Ballroom C

CE: Live CME: 1.50

Chair(s)

Jon Watchko, MD

Professor Emeritus
University of Pittsburgh School of Medicine
Sewickley, Pennsylvania, United States
Cynthia Bearer, MD, PhD

Professor of Pediatrics
Pediatrics
UH Rainbow Babies & Children's Hospital/Case Western Reserve University
Cleveland, Ohio, United States

Disclosure(s):

Jon F. Watchko, MD: McGraw Hill: Intellectual Property including patent beneficiary and royalties (Ongoing)

Cynthia F. Bearer, MD, PhD: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Session

Description: The annual symposium will highlight and elucidate the molecular mechanisms of bilirubin-induced neurotoxicity and their clinical implications. A better understanding of predisposing genetic conditions that are associated with the development of adverse effects on the neonatal brain injury due to severe hyperbilirubinemia will help improve clinical practice and reduce the incidence of bilirubin neurotoxicity (acute and chronic bilirubin encephalopathies) in the USA and globally. The 2022 American Academy of Pediatrics Revised Clinical Practice Guideline for Management of Hyperbilirubinemia will be discussed. Topics:
1. Molecular Mechanisms of Bilirubin Brain Injury – Claudio Tiribelli
2. Overview of the 2022 American Academy of Pediatrics Revised Clinical Practice Guideline for Management of Hyperbilirubinemia – Alex R. Kemper

Learning Objectives:

Understand the molecular mechanisms of bilirubin brain injury
Review the 2022 American Academy of Pediatrics Revised Clinical Practice Guideline for Management of Hyperbilirubinemia
Elucidate the molecular mechanisms of bilirubin-induced neurotoxicity and their clinical implications in the management of hyperbilirubinemia