Neonatal Pulmonology 2: BPD Clinical
Maria Liza M. Espinoza, MD (she/her/hers)
University of Calgary
Calgary, Alberta, Canada
Background: Despite improvements in perinatal care of ELBW infants and improved ventilator approaches and nutritional management, there continues to be evidence of poorer neurodevelopmental (ND) outcomes in ELBW children with BPD. However, there is no sufficient evidence to predict long-term neurodevelopmental outcomes of BPD infants at five years of age in a large study.
To compare composite outcome of death after discharge from hospital and or ND outcomes in ELBW infants with no BPD (NBPD), mild BPD (MBPD) and severe BPD (SBPD) at 5 years of age. At our center, MBPD was defined as oxygen at 36 weeks postmenstrual age with no home oxygen and SBPD was defined as chronic oxygen dependence following discharge home.
In a prospective population-based follow-up cohort study at our regional center, all surviving babies born from Jan 1995 to Dec 2014 weighing ≤1000 g (ELBW) were enrolled in the study. Demographic, neonatal and ND outcome data were compared between the three groups. Outcomes were compared in all 3 groups using univariate and multivariable regression analysis.
There was no association between BPD severity and death or overall ND outcomes at 5 years of age