Carol Vincent, MD (she/her/hers)
pediatric nephrology fellow
Wake Forest Baptist Health - Brenner Children's Hospital
Winston Salem, North Carolina, United States
Of the 30 participants, median GA was 39 weeks [IQR 36, 40] with 27% born preterm (Table 1). No participants had a UPCR ≥0.2 mg/mg. There were 4 participants with UACR ≥30 mg/g who were all term with BW ≥2.5 kg. In adjusted analyses, preterm birth was significantly associated with lower UPCR and UACR and low BW was associated with lower ln-UACR. Lower BW and BW z-score were associated with lower eGFR but only by original, not modified, Schwartz equation (Table 2).
Conclusion(s): Early-life risk factors were associated with modest changes in baseline kidney function in youth with primary HTN, specifically less proteinuria but lower eGFR by one of two measures. Youth with and without early life risk factors may not have differential susceptibility to HTN-associated kidney TOI or it may be too early in the disease course to see a difference. Our study was a pilot study and therefore limited by sample size. Future directions include investigating differential biochemical contributions in kidney and cardiac TOI associated with HTN, as the mechanism and timing may be different in longer-term follow-up.